The objective of the research is to test the methodology of the BASIL (Biphasic Acid Scavenging using Ionic Liquids) technique on a variety of phosphine compounds. We were able to reduce waste, excess solvents and starting materials compared to conventional syntheses for the three compounds, 1a, 1b, and 2b, obtaining yields of 77%, 89%, and 71% respectively. Dichlorophenylphosphine (PhPCl2) was reacted with either HNEt2 or HNEt(Me) along with N‑methylimidazole (MeIm) as the acid scavenger. The reaction forms a biphasic system where [H-MeIm]+Cl- forms a more dense, low melting, ionic liquid. This allows for easy separation of the product from the ionic liquid without the use of solvents. This research also explored making P-S bonds in addition to using chlorodiphenylphosphine (Ph2PCl) as the phosphine reagent.
1a 1b 2b